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Virginia commonwealth university
Viagra shown to protect the heart Some preconditioning occurs naturally. For example, research has shown that people who suffer angina (chest pain) before a heart attack tend to have fewer complications and deaths resulting from the heart attack than those who never suffered angina before the heart attack.
At times preconditioning is planned by doctors for its therapeutic effects. For example, drugs with preconditioning effects can be given to people with heart disease at risk of having a heart attack. Donor hearts removed for transplants and hearts undergoing surgery and placed on cardiopulmonary bypass also can benefit from preconditioning to protect the heart muscle from injury. “My hypothesis was that because Viagra causes dilatation of blood vessels and reduces blood pressure, that such a hypertensive effect may well lead to the release of certain agents, including nitric oxide and bradykinin that could trigger signals in the heart cells, leading to cardio protection -- similar to what is observed after preconditioning,” Kukreja said. Kukreja gave both intravenous and oral doses of Viagra to adult male New Zealand white rabbits. In both cases, Viagra reduced the severity of heart damage in the rabbits. The impact was observed in 30 minutes and lasted almost 24 hours after administration of the drug |
.Kukreja says more extensive clinical trials and research are needed to understand the molecular reasons that Viagra appears to protect a healthy heart against future damage – research that could take another 2-3 years. But the implications already are very exciting to the medical profession.
“There could be great clinical significance from these findings,” said Dr. George Vetrovec, chair of cardiology at VCU’s School of Medicine and world renowned for his research on coronary artery disease. “Everything you do to protect the heart muscle reduces the risk of death and improves the outcome for patients with heart attacks.”
Dr. Vetrovec suggested that Viagra one day might be given before surgery to patients who are scheduled for coronary bypass or angioplasty. In addition, he said, it might be given to patients at high, short-term risk of acute myocardial infarction (heart attack), including those patients with such risk factors as high cholesterol, low HDL, hypertension, diabetes or history of smoking.
Kukreja suggested that Viagra could eventually be used to protect the liver, brain, and other organs against ischemic injury – those injuries that are caused by lack of oxygen.
The University has applied for a patent on the use of sildenafil for cardio protection.
Columbia Greene CC has varsity teams in men's and women's basketball, women's softball, women's soccer, men's baseball and men's golf (women are eligible).
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