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Across the board, both drinking and smoking showed an effect: Higher pack-years and LAPS scores were both significantly associated with lower global cognitive proficiency scores and IQ. When the researchers limited the analysis to those participants who had ever had a diagnosis of alcoholism during their lifetime, they still found a significant association between LAPS scores and IQ, and between pack-years and both IQ and overall cognitive proficiency. In fact, the impact of heavy lifetime smoking history was greater than the effect of lifetime drinking history. This finding, Glass says, means that alcoholism researchers who have consistently found evidence of cognitive deficits among alcoholics — but who have not taken smoking into account in their analysis — may actually be seeing a combined effect of smoking and alcohol consumption among alcoholic study participants who smoke. Further analyses of these data, with smoking separated out as a variable just as hard drug use is often separated, is needed, she says. Glass, who also holds positions in the University of Michigqan's Institute for Social Research and Chronic Pain & Fatigue Research Center, co-authored the paper with Zucker, and with Kenneth Adams, Ph.D., a professor of psychology in psychiatry at U-M and chief of the psychology service at VAAAHCS; Maria Wong, Ph.D., Anne Buu, Ph.D., Jennifer Jester, Ph.D., and Leon Puttler, Ph.D., of UMARC; and Joel Nigg, Ph.D., and Hiram Fitzgerald, Ph.D., of MSU.
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